Ocriplasmin for foveal schisis in X-linked retinoschisis.

Abstract

PURPOSE:

To report a case of foveal schisis in X-linked retinoschisis treated with ocriplasmin.

METHODS:

Case report.

RESULTS:

A 27-year-old man with X-linked retinoschisis was treated with a single intravitreal injection of ocriplasmin. After injection, a posterior vitreous detachment was induced and the macular schisis cavity resolved at 1 week. Central macular thickness on optical coherence tomography decreased from 731 μm to 185 μm, visual acuity remained unchanged, and there were no adverse events. However, the macular schisis cavity recurred at 1 month.

CONCLUSION:

This is the first reported case of using ocriplasmin to treat foveal schisis in X-linked retinoschisis. Although vitreomacular traction was relieved, the schisis cavity recurred shortly after initial closure.

• Authors: Amar Patel, Lawrence Morse
• Journal: Retinal cases & brief reports (Retin Cases Brief Rep) Vol. 9 Issue 3 Pg. 248-51 ( 2015) ISSN: 1937-1578 [Electronic] United States
• PMID: 26002140 (Publication Type: Case Reports, Journal Article)

Chemical References

• Fibrinolytic Agents
• Peptide Fragments
• microplasmin
• Fibrinolysin

Topics

• Adult
• Fibrinolysin (therapeutic use)
• Fibrinolytic Agents (therapeutic use)
• Fovea Centralis
• Genetic Diseases, X-Linked (drug therapy)
• Humans
• Male
• Peptide Fragments (therapeutic use)
• Recurrence
• Retinoschisis (drug therapy)
• Treatment Outcome