Mammalian RNA virus-derived small RNA: biogenesis and functional activity.

Abstract	The role of virus-derived small RNAs (vsRNAs) has been identified as an antiviral mechanism in plants, arthropods, and nematodes. Although mammalian DNA viruses have been observed to encode functional miRNAs, whether RNA virus infection generates functional vsRNAs remains under discussion. This article reviews the most recent reports regarding pathways for generating vsRNAs and the identified vsRNA activity in mammalian cells infected with RNA viruses. We also discuss several hypotheses regarding the roles of mammalian vsRNAs and comment on the potential directions for this research field.
Authors	Kuo-Feng Weng, Po-Ting Hsieh, Hsing-I Huang, Shin-Ru Shih
Journal	Microbes and infection (Microbes Infect) Vol. 17 Issue 8 Pg. 557-63 (Aug 2015) ISSN: 1769-714X [Electronic] France
PMID	25980760 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Copyright	Copyright © 2015 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Chemical References	MicroRNAs RNA, Small Interfering
Topics	Animals DNA Viruses (genetics) Mammals (immunology, virology) MicroRNAs (genetics) RNA Interference RNA Viruses RNA, Small Interfering (genetics)

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