Abstract | BACKGROUND: METHODS: With ethics committee approval and written informed consent, 502 consecutive patients undergoing xenon-based anaesthesia were included in a multicentre prospective observational study. Antiemetic prophylaxis was administered at the discretion of the attending anaesthetists. Postoperative nausea and vomiting and need for antiemetic rescue medication were assessed for 24 h after anaesthesia. Multivariate logistic regression analysis was performed to quantify risk factors for PONV and need for rescue medication. RESULTS: Four hundred and eighty-eight subjects were available for the final analysis. The incidence of PONV in subjects without prophylaxis was lower than expected according to the Apfel Score (28% observed; 42% expected, P<0.001). Independent predictors for PONV were (adjusted odds ratio; 95% confidence interval) female sex (1.76; 1.08-2.89), younger patient age (0.82 per 10 yr; 0.69-0.97), and longer duration of anaesthesia (1.36 per hour; 1.17-1.59). CONCLUSIONS: The incidence of PONV was significantly lower than predicted by the Apfel Score. Female sex, younger age, and longer duration of anaesthesia are risk factors for PONV after xenon-based anaesthesia. CLINICAL TRIAL REGISTRATION: German Federal Institute for Drugs and Medical Devices number AL-PMS-01/07GER.
|
Authors | M S Schaefer, C C Apfel, H-J Sachs, R Stuttmann, B Bein, P H Tonner, M Hein, M Neukirchen, M Reyle-Hahn, P Kienbaum |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 115
Issue 1
Pg. 61-7
(Jul 2015)
ISSN: 1471-6771 [Electronic] England |
PMID | 25962612
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't)
|
Copyright | © The Author 2015. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: [email protected]. |
Chemical References |
- Anesthetics, Inhalation
- Xenon
|
Topics |
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Anesthetics, Inhalation
(adverse effects)
- Female
- Germany
(epidemiology)
- Humans
- Incidence
- Male
- Middle Aged
- Postoperative Nausea and Vomiting
(chemically induced, epidemiology)
- Prospective Studies
- Risk Factors
- Sex Factors
- Time Factors
- Xenon
(adverse effects)
- Young Adult
|