Abstract | BACKGROUND: MATERIALS AND METHODS: We conducted a single center randomized prospective study. Forty-four patients of head trauma with CSF rhinorrhea were divided into two groups, the experimental group (21 patients) was given acetazolamide; and, the control group (23 patients) did not receive the medication. The median duration of CSF leak in days, and the electrolyte changes observed on administration of the medication were recorded in both the groups. RESULTS: Both the experimental and control groups were well matched in terms of age, sex, mechanism of injury, Glasgow Coma Scale (GCS) and the type of skull fracture. The median duration of CSF leak in the control group was of 4 days and in the study group, of 5 days. Acetazolamide caused significant metabolic acidosis and hypokalemia (as shown by decreased serum pH, serum bicarbonate and serum potassium levels) in the experimental group when compared to the control group. CONCLUSIONS:
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Authors | Jaskaran S Gosal, Tenzin Gurmey, Gopi K Kursa, Pravin Salunke, Sunil K Gupta |
Journal | Neurology India
(Neurol India)
2015 Mar-Apr
Vol. 63
Issue 2
Pg. 197-201
ISSN: 0028-3886 [Print] India |
PMID | 25947983
(Publication Type: Journal Article)
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