Abstract | BACKGROUND: OBJECTIVES: Assess and compare the clinical and histological changes induced by different modes of Fractional CO2 laser in treatment of PCA. PATIENTS AND METHODS: Twenty five patients with PCA (16 macular and 9 lichen amyloidosis) were treated by fractional CO2 using; superficial ablation (area A) and deep rejuvenation (area B). Each patient received 4 sessions with 4 weeks intervals. Skin biopsies were obtained from all patients at baseline and one month after the last session. Patients were assessed clinically and histologically ( Congo red staining, polarized light). Patients were followed-up for 3 months after treatment. RESULTS: Both modes yielded significant reduction of pigmentation, thickness, itching, and amyloid deposits (P-value < 0.001). However, the percentage of reduction of pigmentation was significantly higher in area A (P-value = 0.003). Pain was significantly higher in area B. Significant reduction in dermal amyloid deposits denotes their trans-epidermal elimination induced by fractional photothermolysis. CONCLUSION: Both superficial and deep modes of fractional CO2 laser showed comparable efficacy in treatment of PCA. Superficial mode being better tolerated by patients, is recommended as a valid therapeutic option.
|
Authors | Samia M Esmat, Marwa M Fawzi, Heba I Gawdat, Heba S Ali, Safinaz S Sayed |
Journal | Lasers in surgery and medicine
(Lasers Surg Med)
Vol. 47
Issue 5
Pg. 388-95
(Jul 2015)
ISSN: 1096-9101 [Electronic] United States |
PMID | 25946210
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
|
Copyright | © 2015 Wiley Periodicals, Inc. |
Topics |
- Adult
- Amyloidosis, Familial
(pathology, surgery)
- Female
- Humans
- Laser Therapy
(methods)
- Lasers, Gas
(therapeutic use)
- Male
- Middle Aged
- Patient Satisfaction
- Prospective Studies
- Single-Blind Method
- Skin Diseases, Genetic
(pathology, surgery)
- Treatment Outcome
- Young Adult
|