Recent developments in malaria vaccinology.

Abstract

The development of a highly effective malaria vaccine remains a key goal to aid in the control and eventual eradication of this devastating parasitic disease. The field has made huge strides in recent years, with the first-generation vaccine RTS,S showing modest efficacy in a Phase III clinical trial. The updated 2030 Malaria Vaccine Technology Roadmap calls for a second generation vaccine to achieve 75% efficacy over two years for both Plasmodium falciparum and Plasmodium vivax, and for a vaccine that can prevent malaria transmission. Whole-parasite immunisation approaches and combinations of pre-erythrocytic subunit vaccines are now reporting high-level efficacy, whilst exciting new approaches to the development of blood-stage and transmission-blocking vaccine subunit components are entering clinical development. The development of a highly effective multi-component multi-stage subunit vaccine now appears to be a realistic ambition. This review will cover these recent developments in malaria vaccinology.

• Authors: Benedict R Halbroth, Simon J Draper
• Journal: Advances in parasitology (Adv Parasitol) Vol. 88 Pg. 1-49 (Apr 2015) ISSN: 2163-6079 [Electronic] England
• PMID: 25911364 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Malaria Vaccines
• Vaccines, Subunit

Topics

• Animals
• Humans
• Immunization (trends)
• Malaria (prevention & control)
• Malaria Vaccines (immunology, standards)
• Sporozoites (immunology)
• Vaccines, Subunit (immunology)