Abstract | PURPOSE OF REVIEW: To summarize recent findings from genome-wide association studies (GWAS), whole-exome sequencing of patients with familial hypercholesterolemia and 'exome chip' studies pointing to novel genes in LDL metabolism. RECENT FINDINGS: SUMMARY: GWAS, exome sequencing studies, and recently 'exome chip' studies have suggested several novel genes with effects on LDL cholesterol. Novel genes in LDL metabolism will improve our understanding of mechanisms in LDL metabolism, and may lead to the identification of new drug targets to reduce LDL cholesterol levels.
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Authors | Mette Christoffersen, Anne Tybjærg-Hansen |
Journal | Current opinion in lipidology
(Curr Opin Lipidol)
Vol. 26
Issue 3
Pg. 179-87
(Jun 2015)
ISSN: 1473-6535 [Electronic] England |
PMID | 25887678
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Animals
- Cholesterol, LDL
(metabolism)
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Hypercholesterolemia
(genetics)
- Lipid Metabolism
(genetics)
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