Regulatory function of CD4+CD25++ T cells in patients with myasthenia gravis is associated with phenotypic changes and STAT5 signaling: 1,25-Dihydroxyvitamin D3 modulates the suppressor activity.

Abstract

Regulatory T cells were investigated in early-onset (EO) and late-onset (LO) myasthenia gravis patients with anti-acetylcholine receptor antibody (AChR-MG). Alterations in PD-1 and PD-L1 on CD4(+)CD25(++) (Treg) and responder T cells (Tresp, CD4(+)CD25(-)) were observed in LOMG patients. GITR was decreased on CD4(+)CD25(++) of all patients. Decrease of FOXP3 was associated with lower phosphorylation of STAT5.1,25-dihydroxyvitamin D3 (VitD3) increased suppression in co-culture with a stronger effect in patients by acting possibly both on cell groups. Changes in surface molecules and intracellular pathways contribute to the defects of Treg in non-thymomatous AChR-MG and VitD3 can have modulatory effects.

• Authors: Mahdi Alahgholi-Hajibehzad, Piraye Oflazer, Fikret Aysal, Hacer Durmuş, Yeşim Gülşen-Parman, Alexander Marx, Feza Deymeer, Güher Saruhan-Direskeneli
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 281 Pg. 51-60 (Apr 15 2015) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 25867468 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• IL2RA protein, human
• Interleukin-2 Receptor alpha Subunit
• STAT5 Transcription Factor
• Calcitriol

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• CD4-Positive T-Lymphocytes (physiology)
• Calcitriol (pharmacology)
• Cells, Cultured
• Coculture Techniques
• Female
• Humans
• Interleukin-2 Receptor alpha Subunit (physiology)
• Male
• Middle Aged
• Myasthenia Gravis (metabolism)
• Phenotype
• STAT5 Transcription Factor (metabolism)
• Signal Transduction (drug effects, physiology)
• Young Adult