Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias.

Abstract

In the last few years, a lot of publications suggested that disabling cerebellar ataxias may develop through immune-mediated mechanisms. In this consensus paper, we discuss the clinical features of the main described immune-mediated cerebellar ataxias and address their presumed pathogenesis. Immune-mediated cerebellar ataxias include cerebellar ataxia associated with anti-GAD antibodies, the cerebellar type of Hashimoto's encephalopathy, primary autoimmune cerebellar ataxia, gluten ataxia, Miller Fisher syndrome, ataxia associated with systemic lupus erythematosus, and paraneoplastic cerebellar degeneration. Humoral mechanisms, cell-mediated immunity, inflammation, and vascular injuries contribute to the cerebellar deficits in immune-mediated cerebellar ataxias.

• Authors: Hiroshi Mitoma, Keya Adhikari, Daniel Aeschlimann, Partha Chattopadhyay, Marios Hadjivassiliou, Christiane S Hampe, Jérôme Honnorat, Bastien Joubert, Shinji Kakei, Jongho Lee, Mario Manto, Akiko Matsunaga, Hidehiro Mizusawa, Kazunori Nanri, Priya Shanmugarajah, Makoto Yoneda, Nobuhiro Yuki
• Journal: Cerebellum (London, England) (Cerebellum) Vol. 15 Issue 2 Pg. 213-32 (Apr 2016) ISSN: 1473-4230 [Electronic] United States
• PMID: 25823827 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Glutens

Topics

• Animals
• Cerebellar Ataxia (diagnosis, physiopathology)
• Cerebellum (physiopathology)
• Consensus
• Encephalitis (physiopathology)
• Glutens (metabolism)
• Hashimoto Disease (physiopathology)
• Humans
• Neuroimmunomodulation (physiology)