Abstract | BACKGROUND/AIM: MATERIALS AND METHODS: Immunohistochemistry was performed to probe the differential expression of LIF and LIFR in oviduct tissues among a control group (including NP group, n = 11; and IP group, n = 12), tubal pregnancy group (Ect-N group, n = 31; and Ect-A group, n = 40), and chronically inflamed group (including Inf-S group, n = 11; and Inf-P group, n = 9), followed by semiquantitative analysis. RESULTS: Semiquantitative immunohistochemical analysis demonstrated that there was no significant difference in LIF expression in either the epithelial or stromal cells of oviduct tissues between the tubal pregnancy group and the control group (P < 0.05). However, LIF expression was remarkably elevated in the Inf-S and Inf-P group compared to the other groups (P < 0.05). In the epithelial cells of the fallopian tubes, LIFR expression was highest in the chronically inflamed group, followed by the tubal pregnancy group, outnumbering the control group (P < 0.05). More interestingly, an opposite expression trend of LIFR was observed in the stromal cells of the fallopian tubes among these groups (P <0.05). CONCLUSION: Aberratn expression of LIF and LIFR might be associated with the occurrence of tubal pregnancy.
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Authors | Yong Li, Lizhou Sun, Denmei Zhao, Jun Ouyang, Mei Xiang |
Journal | Turkish journal of medical sciences
(Turk J Med Sci)
Vol. 45
Issue 1
Pg. 214-20
( 2015)
ISSN: 1300-0144 [Print] Turkey |
PMID | 25790555
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- LIF protein, human
- Leukemia Inhibitory Factor
- Receptors, OSM-LIF
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Topics |
- Adolescent
- Adult
- Fallopian Tubes
(chemistry, cytology, metabolism)
- Female
- Humans
- Immunohistochemistry
- Leukemia Inhibitory Factor
(analysis, metabolism)
- Pregnancy
- Pregnancy, Tubal
(metabolism)
- Receptors, OSM-LIF
(analysis, metabolism)
- Salpingitis
(metabolism)
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