[Acellular vaccines (DTPa/dTpa) against whooping cough, protection duration].

Abstract

INTRODUCTION:

An increase in whooping cough in most of the developed countries has been detected in the last decade.

OBJECTIVE:

To determine whether the administration of dTpa vaccine instead of DTPa fifth dose is contributing to the appearance of these cases.

METHODS:

A descriptive study based on cases of whooping cough reported during an epidemic period in the city of Alicante in the first 5 months of 2014. Only pertussis cases confirmed by PCR were included in the study, and only those vaccinated with 5 doses were included in the analysis of the period of protection.

RESULTS:

A total of 104 cases of pertussis confirmed by PCR were reported, with 85 cases (82%) having had 5 doses of vaccine. The mean time and standard deviation (SD) of protection was 2.1±1.1 years with dTpa, and 5.1±1.5 years with DTPa (p<.001). In the protection, adjusted for age, it was observed that, after 3 years, only 47.6% of people vaccinated with dTpa were still protected, while people vaccinated with DTPa were 100% protected (P<.001).

CONCLUSIONS:

This study found that people who were properly vaccinated against pertussis and received their last re-vaccination dose with dTpa had a shorter period of protection than those who were vaccinated with DTPa.

• Authors: M Vicenta Rigo-Medrano, José L Mendoza-García, Adelina Gimeno-Gascón, Jorge Roda-Ramón, Israel Cremades-Bernabeú, Pedro Antequera-Rodríguez, Pedro J Alcalá-Minagorre, Victoria Ortiz-de la Tabla, Juan Carlos Rodríguez-Díaz
• Journal: Enfermedades infecciosas y microbiologia clinica (Enferm Infecc Microbiol Clin) Vol. 34 Issue 1 Pg. 23-8 (Jan 2016) ISSN: 1578-1852 [Electronic] Spain
• Vernacular Title: Vacunas acelulares (DTPa/dTpa) contra la tos ferina: duración de la protección.
• PMID: 25735715 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

Chemical References

• Diphtheria-Tetanus-acellular Pertussis Vaccines
• Pertussis Vaccine
• Vaccines, Acellular

Topics

• Diphtheria-Tetanus-acellular Pertussis Vaccines (therapeutic use)
• Humans
• Immunization, Secondary
• Pertussis Vaccine (therapeutic use)
• Vaccination
• Vaccines, Acellular (therapeutic use)
• Whooping Cough (prevention & control)