Abstract | OBJECTIVE: METHODS: A retrospective review of the medical records of patients with autoimmune diseases hospitalized to a tertiary center over a 5-year study period was carried out. Patient demographics, mean glucocorticoid dose (in the last 1 month), and the outcomes of patients who developed PCP were analyzed. RESULTS: The incidence rate of PCP infection was 75 per 100,000 patients per year. The in-hospital mortality was 50%, and all those who died were on high-dose glucocorticoid at the time of PCP diagnosis. There was a significant difference between the occurrence of PCP in patients who were on high-dose vs non-high-dose glucocorticoid (df = 1, P = 0.009), with a relative risk of 19 (P = 0.010; 95% confidence interval, 2.0-182.8). The mean oral prednisolone dose of patients who developed PCP and those who did not were 55.5 versus 10.7 mg, respectively, P = 0.002. CONCLUSION:
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Authors | Li-Ching Chew, Liza Marie Maceda-Galang, York Kiat Tan, Bibhas Chakraborty, Julian Thumboo |
Journal | Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
(J Clin Rheumatol)
Vol. 21
Issue 2
Pg. 72-5
(Mar 2015)
ISSN: 1536-7355 [Electronic] United States |
PMID | 25710857
(Publication Type: Journal Article)
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Chemical References |
- Anti-Infective Agents
- Glucocorticoids
- Trimethoprim, Sulfamethoxazole Drug Combination
- Prednisolone
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Topics |
- Adult
- Aged
- Anti-Infective Agents
- Autoimmune Diseases
(complications, drug therapy)
- Female
- Glucocorticoids
(administration & dosage, adverse effects)
- Humans
- Incidence
- Male
- Middle Aged
- Pneumocystis carinii
- Pneumonia, Pneumocystis
(diagnosis, drug therapy, epidemiology)
- Prednisolone
(administration & dosage, adverse effects)
- Retrospective Studies
- Risk Factors
- Trimethoprim, Sulfamethoxazole Drug Combination
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