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The three-body problem of therapy with induced pluripotent stem cells.

Abstract
Regenerative medicine has a three-body problem: alignment of the dynamics of the genome, stem cell and patient. Focusing on the rare inherited fragile skin disorder epidermolysis bullosa, three recent innovative studies have used induced pluripotent stem cells and gene correction, revertant mosaicism or genome editing to advance the prospects of better cell-based therapeutics to restore skin structure and function for epidermolysis bullosa and potentially other inherited diseases.
AuthorsJakub Tolar, John A McGrath
JournalGenome medicine (Genome Med) Vol. 7 Issue 1 Pg. 15 ( 2015) ISSN: 1756-994X [Print] England
PMID25705260 (Publication Type: Journal Article)

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