Abstract | OBJECTIVE: METHODS: Liver and biliary tract imaging and relevant clinical details were reviewed in 71 patients (37, 52% boys) treated with PN for >3 months. Types of lipid infused were compared with regard to hepatobiliary abnormalities. RESULTS: In total 369 abdominal ultrasounds were performed in 71 patients of age between 3 months and 17 years. Underlying diagnoses were short bowel syndrome in 20 (28%), small intestinal enteropathy in 34 (48%), and motility disorder in 17 (24%). A total of 67 (94%) children had 362/369 scans on lipid-containing PN. Of the total, 15 (21%) patients had gallstones, 8 (11%) had sludge, and both were detected in 7 (10%) children. The gallstones/sludge resolved in 7 patients (10%) and persisted in 10 (13%). In 6 patients, sludge progressed to form discrete gallstones, and in 9 children, gallstones led to biliary duct dilatation. Four (6%) patients underwent cholecystectomy. Fewer children had abnormalities with the newer mixed lipid emulsion (P = 0.005). There was a higher prevalence of sludge (P = 0.01) on pure soya lipid. Predictors for sludge were young age at PN (P = 0.001), lack of enteral feed (P < 0.001), and motility disorder with stoma (P = 0.002). CONCLUSIONS: Hepatobiliary pathology is common in children on PN. The use of mixed lipid was associated with less biliary complications and should be the first choice of treatment in children.
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Authors | Judith Pichler, Tom Watson, Kieran McHugh, Susan Hill |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 61
Issue 2
Pg. 253-9
(Aug 2015)
ISSN: 1536-4801 [Electronic] United States |
PMID | 25688480
(Publication Type: Journal Article)
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Chemical References |
- Fat Emulsions, Intravenous
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Topics |
- Adolescent
- Bile
(diagnostic imaging)
- Biliary Tract Diseases
(diagnostic imaging, epidemiology)
- Child
- Child, Preschool
- Fat Emulsions, Intravenous
(administration & dosage, adverse effects, therapeutic use)
- Female
- Gallstones
(diagnostic imaging, epidemiology)
- Humans
- Infant
- Intestinal Diseases
(therapy)
- Intestine, Small
(pathology)
- Liver Diseases
(diagnostic imaging, epidemiology)
- Male
- Parenteral Nutrition
(adverse effects, methods)
- Short Bowel Syndrome
(therapy)
- Ultrasonography
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