Abstract |
This study was undertaken to describe the clinical and imaging characteristics of patients with chorea associated with nonketotic hyperglycemia (C-NKH) in comparison with patients with chorea associated with uremia (C-URE). We retrospectively analyzed the clinical data of consecutive 10 C-NKH and five C-URE patients who were treated between January 1, 2001 and January 31, 2013. Women were more frequently affected by C-NKH (70% vs. 30%) and C-URE (80% vs. 20%) compared with men. The C-NKH patients demonstrated T1-hyperintense and inhomogeneous lesions in the basal ganglia, whereas C-URE patients demonstrated T2-hyperintense and homogeneous lesions in the basal ganglia. The mean time for chorea resolution after treatment was significantly shorter in C-NKH patients than in C-URE patients (4.4 ± 2.6 d vs. 73.8 ± 14.2 d, respectively; P = 0.005). The clinical and imaging features are remarkably different between C-NKH and C-URE patients, suggesting distinct pathogenic mechanisms.
|
Authors | Young Jin Kim, Sang Joon Kim, Juyeon Kim, Mi-Jung Kim, Ki-Ju Kim, Hyukjun Yoon, Sung Reul Kim, Sun Ju Chung |
Journal | Movement disorders : official journal of the Movement Disorder Society
(Mov Disord)
Vol. 30
Issue 3
Pg. 419-22
(Mar 2015)
ISSN: 1531-8257 [Electronic] United States |
PMID | 25649292
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | © 2015 International Parkinson and Movement Disorder Society. |
Topics |
- Adult
- Aged
- Aged, 80 and over
- Brain
(pathology)
- Chorea
(diagnosis, etiology)
- Diabetes Complications
(physiopathology)
- Female
- Follow-Up Studies
- Humans
- Hyperglycemia
(complications, etiology)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Retrospective Studies
- Uremia
(complications)
|