[Leptin, adiponectin and sex hormone in benign acanthosis nigricans of males].

Abstract

OBJECTIVE:

To explore the serum levels of leptin, adiponectin and sex hormone and their relationship in benign acanthosis nigricans of males.

METHODS:

A total of 15 males patients with benign acanthosis nigricans were recruited from January 2010 to December 2013. The serum concentrations of leptin, adiponectin and sex hormone were measured with radioimmunoassay and enzyme-linked immunoabsorbant assay (ELISA) respectively.

RESULTS:

As compared with normal control, the values of body mass, body mass index and %Fat were much higher in benign acanthosis nigricans of males ((88 ± 6) vs (62 ± 5) kg, (31.7 ± 2.1) vs (22.2 ± 2.7) kg/m(2), 33.3% ± 2.6% vs 29.0% ± 5.8%, all P < 0.05) , leptin was much higher ((8.0 ± 1.1) vs (4.5 ± 1.5) µg/L, P < 0.01) , adiponectin was much lower ((27.7 ± 4.8) vs (38.6 ± 5.8) µg/L, P < 0.01) , estradiol and testosterone were much higher ((112 ± 28) vs (38 ± 7) pmol/L, (7.3 ± 1.9) vs (3.9 ± 2.0) nmol/L, both P < 0.01), luteinizing hormone was much lower ((128 ± 11) vs (155 ± 24) U/L, P < 0.01) . And prolactin and follicle stimulating hormone were not significantly different between two groups (both P > 0.05).

CONCLUSIONS:

Benign acanthosis nigricans is associated with abnormal levels of lepin, adiponectin and sex hormone. And there may be some relationship between the abnormal levels of lepin and sex hormone in benign acanthosis nigricans.

• Authors: Ying Wang, Xinyuan Liu, Zheng Wang, Yilei Li, Tong Chen, Bo Li, Ning Zhai, Jiuhong Li
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 94 Issue 44 Pg. 3475-7 (Dec 02 2014) ISSN: 0376-2491 [Print] China
• PMID: 25622736 (Publication Type: Journal Article)

Chemical References

• Adiponectin
• Gonadal Steroid Hormones
• Leptin
• Testosterone
• Estradiol
• Prolactin
• Luteinizing Hormone
• Follicle Stimulating Hormone

Topics

• Acanthosis Nigricans
• Adiponectin
• Body Mass Index
• Estradiol
• Follicle Stimulating Hormone
• Gonadal Steroid Hormones
• Humans
• Leptin
• Luteinizing Hormone
• Male
• Prolactin
• Skin
• Testosterone