Calcipotriene 0.005%--betamethasone dipropionate 0.064% ointment versus topical suspension in the treatment of plaque psoriasis: a randomized pilot study of patient preference.

Abstract	Vehicle formulation plays a major role in patient adherence to topical psoriasis treatments. The objective of this study was to conduct a preliminary assessment of patient preference for ointment versus topical suspension formulations of calcipotriene 0.005%-betamethasone dipropionate 0.064% for treatment of plaque psoriasis. In our small cohort of 20 participants with mild to moderate plaque psoriasis, the topical suspension formulation was preferred over the ointment, though the difference was not statistically significant (P=.32). Overall, the topical suspension was rated as moderately appealing, while the ointment was rated as slightly appealing (P=.06). Subgroup analyses were limited due to the small sample size. The results of this study may provide clinicians with an alternative topical treatment of plaque psoriasis that provides the benefits of a combination product. In clinical practice, it may be best to offer patients both formulations and they can choose the product that is right for them.
Authors	Laura F Sandoval, Karen E Huang, Jessica Harrison, Adele Clark, Steven R Feldman
Journal	Cutis (Cutis) Vol. 94 Issue 6 Pg. 304-9 (Dec 2014) ISSN: 0011-4162 [Print] United States
PMID	25566573 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Inflammatory Agents Antineoplastic Agents Dermatologic Agents Drug Combinations Ointments Suspensions calcipotriene betamethasone-17,21-dipropionate Betamethasone Calcitriol
Topics	Administration, Topical Adult Anti-Inflammatory Agents (administration & dosage) Antineoplastic Agents (administration & dosage) Betamethasone (administration & dosage, analogs & derivatives) Calcitriol (administration & dosage, analogs & derivatives) Dermatologic Agents (administration & dosage) Drug Combinations Female Humans Male Middle Aged Ointments Patient Preference Pilot Projects Psoriasis (drug therapy, physiopathology, psychology) Severity of Illness Index Suspensions Treatment Outcome

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