Treatment outcomes of intensity-modulated radiotherapy versus 3D conformal radiotherapy for patients with maxillary sinus cancer in the postoperative setting.

Abstract

BACKGROUND:

In this study, we compared the treatment outcomes of postoperative 3D conformal radiotherapy (RT) and intensity-modulated radiotherapy (IMRT) for patients with maxillary sinus carcinoma.

METHODS:

Fifty-four patients underwent surgery and postoperative RT, of whom 27 (50%) had squamous cell carcinoma and 14 (26%) had adenoid cystic carcinoma. Nineteen patients (35%) were treated with IMRT and 35 patients (65%) received 3D conformal RT. The median radiation dose for 3D conformal RT and IMRT were 62.1 and 63 Gy, respectively.

RESULTS:

IMRT produced significantly superior radiation dose distribution to planning target volumes (PTVs) than 3D conformal RT. Over a median follow-up of 60 months, IMRT provided better 3-year locoregional recurrence-free survival (89.2% vs 59.5%; p = .035) and distant metastasis-free survival (94.7% vs 55.3%; p = .042) rates than 3D conformal RT.

CONCLUSION:

Postoperative IMRT for patients with maxillary sinus carcinoma resulted in excellent disease control, and should be considered as the first treatment option in these cases. © 2015 Wiley Periodicals, Inc. Head Neck 38: E207-E213, 2016.

• Authors: Yang-Gun Suh, Chang Geol Lee, Hyunju Kim, Eun Chang Choi, Se Hun Kim, Chang-Hoon Kim, Ki Chang Keum
• Journal: Head & neck (Head Neck) Vol. 38 Suppl 1 Pg. E207-13 (04 2016) ISSN: 1097-0347 [Electronic] United States
• PMID: 25538027 (Publication Type: Comparative Study, Journal Article)
• Copyright: © 2015 Wiley Periodicals, Inc.

Topics

• Adult
• Aged
• Carcinoma, Adenoid Cystic (radiotherapy)
• Carcinoma, Squamous Cell (radiotherapy)
• Female
• Humans
• Male
• Maxillary Sinus Neoplasms (radiotherapy)
• Middle Aged
• Radiotherapy Dosage
• Radiotherapy, Conformal
• Radiotherapy, Intensity-Modulated
• Treatment Outcome