Leptomeningeal rheumatoid nodules: diagnosis and failed therapeutics.

Abstract

A 67-year-old woman presented with recurrent transient ischaemic attack-like episodes over a 2 year period. Nodular enhancing leptomeningeal changes were detected on MRI and were consistent with meningeal rheumatoid nodules on biopsy. The patient's nodular disease continued to progress and regress clinically and radiologically irrespective of disease modifying agents and peripheral and serological rheumatoid arthritis control. This patient's unique presentation and diagnostic work-up is discussed alongside the dilemma of therapeutic management of meningeal rheumatoid nodules.

• Authors: Cassie Nesbitt, Luke Willshire, Doreen Quan, Cameron Shaw, Peter Batchelor
• Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 22 Issue 2 Pg. 425-8 (Feb 2015) ISSN: 1532-2653 [Electronic] Scotland
• PMID: 25533052 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Antirheumatic Agents

Topics

• Aged
• Antirheumatic Agents (adverse effects, therapeutic use)
• Arachnoid Cysts (diagnosis, therapy)
• Arthritis, Rheumatoid (complications, drug therapy)
• Biopsy
• Disease Progression
• Female
• Humans
• Ischemic Attack, Transient (etiology)
• Magnetic Resonance Imaging
• Recurrence
• Rheumatoid Nodule (diagnosis, therapy)
• Treatment Failure
• Treatment Outcome