Association of urinary cesium with breast cancer risk.

Abstract

BACKGROUND:

The aim of this study is to examine the association of urinary cesium with breast cancer risk.

MATERIALS AND METHODS:

We collected survey data and urine specimens from 240 women with incident invasive breast cancer before their treatment and 246 age-matched female controls between October 2009 and July 2010. Urinary concentrations of cesium were determined by inductively coupled plasma mass spectrometry. Interviews were conducted by face-to-face to obtain information on potential breast cancer risk factors. Logistic regression analysis was used to estimate the associations.

RESULTS:

Creatinine-adjusted levels [median (25th, 75th) ug/g] of cesium in cases and controls were 17.6 (13.1, 24.0) and 19.3 (15.3, 25.7), respectively. After adjustment for potential risk factors, women in the second and highest tertile of cesium showed a decreased risk of breast cancer in a dose-dependent manner as compared with those in the lowest tertile [ORs and 95% CIs: 0.75 (0.46- 1.22) and 0.50 (0.30-0.82), respectively]. This decrease was more evident in women with ER positive or localized clinical stage in an exploratory stratification analysis.

CONCLUSIONS:

These findings suggest that cesium may have anticancer efficacy and urinary cesium has potential as a biomarker for breast cancer risk assessment.

• Authors: Ya-Chao Qin, Lu-Ying Tang, Yi Su, Li-Juan Chen, Feng-Xi Su, Ying Lin, Ai-Hua Zhang, Ze-Fang Ren
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 15 Issue 22 Pg. 9785-90 ( 2014) ISSN: 2476-762X [Electronic] Thailand
• PMID: 25520105 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Cesium

Topics

• Biomarkers, Tumor (urine)
• Breast Neoplasms (etiology, prevention & control, urine)
• Case-Control Studies
• Cesium (adverse effects, urine)
• Female
• Follow-Up Studies
• Humans
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Staging
• Prognosis
• Risk Assessment
• Risk Factors
• Surveys and Questionnaires