TroVax in colorectal cancer.

Abstract

Currently, the backbone of therapy for metastatic disease is cytotoxic chemotherapy, along with the recent addition of targeted therapy based on molecular markers with KRAS testing. Despite the improvement in survival for metastatic colon cancer, newer agents are still needed. The clinical activity of TroVax in metastatic colon cancer has been studied in a small number of clinical trials. There is evidence that supports the vaccine's ability to induce humoral and cellular responses, as demonstrated by positive 5T4 and MVA-specific antibody titers and cellular proliferation assays. Future strategies should focus on investigating the immunomodulatory effects of chemotherapy in conjunction with TroVax, understanding the optimal dosing and schedule of the combination, and examining potential predictive biomarkers to determine which patients may benefit from immunotherapy from those who do not.

• Authors: Julie Rowe, Putao Cen
• Journal: Human vaccines & immunotherapeutics (Hum Vaccin Immunother) Vol. 10 Issue 11 Pg. 3196-200 ( 2014) ISSN: 2164-554X [Electronic] United States
• PMID: 25483641 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Cancer Vaccines
• Carcinoembryonic Antigen
• Membrane Glycoproteins
• Organoplatinum Compounds
• TroVax
• Vaccines, DNA
• trophoblastic glycoprotein 5T4, human
• Leucovorin
• Fluorouracil
• Camptothecin

Topics

• Antineoplastic Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Camptothecin (analogs & derivatives, therapeutic use)
• Cancer Vaccines (immunology, therapeutic use)
• Carcinoembryonic Antigen (immunology)
• Carcinoma, Renal Cell (pathology, prevention & control, therapy)
• Colonic Neoplasms (pathology, prevention & control, therapy)
• Fluorouracil (therapeutic use)
• Humans
• Immunotherapy (methods)
• Kidney Neoplasms (pathology, prevention & control, therapy)
• Leucovorin (therapeutic use)
• Membrane Glycoproteins (immunology)
• Organoplatinum Compounds (therapeutic use)
• Vaccination
• Vaccines, DNA
• Vaccinia virus (immunology)