Longitudinal changes in C-reactive protein, proform of eosinophil major basic protein, and pregnancy-associated plasma protein-A during weight changes in obese children.

Abstract

BACKGROUND:

Childhood obesity is associated with several complications, including cardiovascular comorbidity. Several biomarkers, such as high-sensitive C-reactive protein (hs-CRP), proform of eosinophil major basic protein (Pro-MBP) and pregnancy associated plasma protein-A (PAPP-A), have equally been linked to increased cardiovascular susceptibility. This study investigates these biomarkers during weight loss and regain in obese children.

MATERIALS AND METHODS:

A longitudinal study during a 12-week weight loss program with a 28 months follow-up was conducted. Anthropometrics and plasma concentrations of hs-CRP, Pro-MBP, and PAPP-A were measured at baseline; at days 14, 33 and 82 during weight loss; and at months 10, 16, and 28 during follow-up.

RESULTS:

Fifty-three boys and 62 girls aged 8-15 years with a median body mass index (BMI) standard deviation score (SDS) at baseline of 2.78 (boys), and 2.70 (girls) were included. Ninety children completed the weight loss program and 68 children entered the follow-up program. Pro-MBP and PAPP-A, but not hs-CRP, exhibited individual-specific levels (tracking) during weight loss and regain. The PAPP-A/Pro-MBP correlation was strong, whereas the hs-CRP/PAPP-A correlation was weak during weight fluctuations.

CONCLUSION:

Hs-CRP changes reflect weight changes. PAPP-A and Pro-MBP exhibited tracking during weight perturbations and may contribute as early risk markers of cardiovascular susceptibility.

• Authors: Ulrik Lausten-Thomsen, Michael Gamborg, Christine Bøjsøe, Paula L Hedley, Christian Munch Hagen, Michael Christiansen, Jens-Christian Holm
• Journal: Journal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 28 Issue 3-4 Pg. 393-8 (Mar 2015) ISSN: 2191-0251 [Electronic] Germany
• PMID: 25460282 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Protein Precursors
• C-Reactive Protein
• Eosinophil Major Basic Protein
• Pregnancy-Associated Plasma Protein-A

Topics

• Adolescent
• Body Weight
• C-Reactive Protein (analysis, metabolism)
• Child
• Eosinophil Major Basic Protein (analysis, blood)
• Female
• Follow-Up Studies
• Humans
• Longitudinal Studies
• Male
• Pediatric Obesity (blood, therapy)
• Pregnancy-Associated Plasma Protein-A (analysis, metabolism)
• Protein Precursors (blood)
• Weight Reduction Programs