Efficacy of platelet-rich plasma as a scaffold in regenerative endodontic treatment.

Abstract

INTRODUCTION:

Current research is concerned with discovering better scaffolds for use in regenerative endodontic treatment. This study aimed to clinically and radiographically evaluate the efficacy of platelet-rich plasma (PRP) used as a scaffold in regenerative endodontic treatment and compare it with that of a conventional blood clot (BC) scaffold.

METHODS:

A total of 20 necrotic, single-rooted immature teeth were randomly distributed into 2 groups. After disinfecting the root canal space with triple antibiotic paste (1:1:1 ciprofloxacin, metronidazole, and cefaclor), a tissue scaffold was created by using either PRP or BC and covered with white mineral trioxide aggregate. Clinical and radiographic follow-up examinations were performed once every 3 months during an 18-month period. Differences in root area were calculated from preoperative and postoperative radiographs. Fisher exact and Mann-Whitney U tests were used to evaluate differences between groups, with P value <.05 considered to be statistically significant.

RESULTS:

All 20 teeth were clinically asymptomatic during 18-month follow-up period; however, 1 tooth in the BC group exhibited periapical pathosis and was judged radiographically unsuccessful. Complete apical closure was observed in a mean of 8.1 months in the PRP group compared with 9 months in the BC group. The PRP group exhibited 9.86% increase in root area, compared with 12.6% increase in the BC group. The difference in success rates between the groups was not statistically significant (P > .05).

CONCLUSIONS:

PRP successfully created a scaffold for regenerative endodontic treatment; however, treatment outcomes did not differ significantly between PRP and conventional BC scaffold.

• Authors: Tugba Bezgin, Ayca Dilara Yilmaz, Burcu Nihan Celik, Mehmet Eray Kolsuz, Hayriye Sonmez
• Journal: Journal of endodontics (J Endod) Vol. 41 Issue 1 Pg. 36-44 (Jan 2015) ISSN: 1878-3554 [Electronic] United States
• PMID: 25459571 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

Chemical References

• Aluminum Compounds
• Anti-Bacterial Agents
• Calcium Compounds
• Drug Combinations
• Oxides
• Root Canal Filling Materials
• Silicates
• mineral trioxide aggregate

Topics

• Adolescent
• Aluminum Compounds
• Anti-Bacterial Agents (administration & dosage)
• Calcium Compounds
• Child
• Dental Pulp
• Dental Pulp Necrosis (pathology, therapy)
• Drug Combinations
• Female
• Humans
• Male
• Oxides
• Platelet-Rich Plasma
• Random Allocation
• Regeneration (drug effects, physiology)
• Root Canal Filling Materials (therapeutic use)
• Root Canal Preparation
• Root Canal Therapy (methods)
• Silicates
• Thrombosis
• Tissue Scaffolds
• Tooth Apex (drug effects, pathology)
• Tooth Root (pathology)
• Treatment Outcome