Reconnaissance of 47 antibiotics and associated microbial risks in seafood sold in the United States.

Abstract

Aquaculture production has nearly tripled in the last two decades, bringing with it a significant increase in the use of antibiotics. Using liquid chromatography/tandem mass spectrometry (LC-MS/MS), the presence of 47 antibiotics was investigated in U.S. purchased shrimp, salmon, catfish, trout, tilapia, and swai originating from 11 different countries. All samples (n=27) complied with U.S. FDA regulations and five antibiotics were detected above the limits of detection: oxytetracycline (in wild shrimp, 7.7ng/g of fresh weight; farmed tilapia, 2.7; farmed salmon, 8.6; farmed trout with spinal deformities, 3.9), 4-epioxytetracycline (farmed salmon, 4.1), sulfadimethoxine (farmed shrimp, 0.3), ormetoprim (farmed salmon, 0.5), and virginiamycin (farmed salmon marketed as antibiotic-free, 5.2). A literature review showed that sub-regulatory levels of antibiotics, as found here, can promote resistance development; publications linking aquaculture to this have increased more than 8-fold from 1991 to 2013. Although this study was limited in size and employed sample pooling, it represents the largest reconnaissance of antibiotics in U.S. seafood to date, providing data on previously unmonitored antibiotics and on farmed trout with spinal deformities. Results indicate low levels of antibiotic residues and general compliance with U.S. regulations. The potential for development of microbial drug resistance was identified as a key concern and research priority.

• Authors: Hansa Y Done, Rolf U Halden
• Journal: Journal of hazardous materials (J Hazard Mater) Vol. 282 Pg. 10-7 (Jan 23 2015) ISSN: 1873-3336 [Electronic] Netherlands
• PMID: 25449970 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Water Pollutants, Chemical

Topics

• Animals
• Anti-Bacterial Agents (analysis, standards)
• Drug Resistance, Microbial
• Environmental Exposure (standards)
• Fishes
• Food Contamination (analysis, legislation & jurisprudence)
• Government Regulation
• Penaeidae
• Risk Assessment
• Seafood (analysis, standards)
• United States
• Water Pollutants, Chemical (analysis, standards)