Abstract | BACKGROUND/AIM: MATERIALS AND METHODS: A 76-member combined epigenetics and phosphatase small-molecule inhibitor library was screened for anti-proliferative activity against the MUC4(+) gemcitabine-resistant pancreatic cancer cell line Capan-1, followed by high-content screening of protein expression. RESULTS: CONCLUSION:
Apicidin appears to be a novel anti-proliferative agent against pancreatic cancer cells that may reverse chemoresistance by epigenetically regulating MUC4 expression.
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Authors | Daniel Ansari, Carlos Urey, Katarzyna Said Hilmersson, Monika P Bauden, Fredrik Ek, Roger Olsson, Roland Andersson |
Journal | Anticancer research
(Anticancer Res)
Vol. 34
Issue 10
Pg. 5269-76
(Oct 2014)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 25275019
(Publication Type: Journal Article)
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Copyright | Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. |
Chemical References |
- Antimetabolites, Antineoplastic
- Histone Deacetylase Inhibitors
- Mucin-4
- Peptides, Cyclic
- Small Molecule Libraries
- apicidin
- Deoxycytidine
- Gemcitabine
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Topics |
- Antimetabolites, Antineoplastic
(pharmacology)
- Cell Line, Tumor
- Deoxycytidine
(analogs & derivatives, pharmacology)
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
(genetics)
- Drug Screening Assays, Antitumor
- Epigenesis, Genetic
(drug effects)
- Gene Expression Regulation, Neoplastic
(drug effects)
- Histone Deacetylase Inhibitors
(pharmacology)
- Humans
- Mucin-4
(genetics)
- Pancreatic Neoplasms
(drug therapy, genetics)
- Peptides, Cyclic
(pharmacology)
- Small Molecule Libraries
- Gemcitabine
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