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Laser diode coupled with optical fiber for applications in photodynamic therapy.

Abstract
A diode laser with roughly 480 mW/cm2 emission at 776 nm was developed and engineered to obtain a uniform illumination of tumour cells deposited on Petri dishes having an external diameter of 5 cm. The efficacy of the apparatus in inducing photocytotoxic effects was successfully checked by irradiation of pigmented melanoma cells in the presence of a photosensitizer, Si(IV)-naphthalocyanine, having intense absorption bands at 776 nm. Our results open interesting prospects for extending photodynamic therapy to highly pigmented tumours.
AuthorsW Cecchetti, R Biolo, G Jori
JournalTechnology and health care : official journal of the European Society for Engineering and Medicine (Technol Health Care) Vol. 1 Issue 3 Pg. 219-22 (Jan 01 1994) ISSN: 0928-7329 [Print] Netherlands
PMID25273370 (Publication Type: Journal Article)

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