Abstract | OBJECTIVE: METHODS: Thirty-two Kun-Ming mice were randomly divided into 4 groups (8 mice in each group): Group C (mice underwent a sham procedure and saline was infused subcutaneously over a period of 30 min), Group I (mice underwent a surgical incision and the same volume of saline), Group R (mice underwent a sham procedure and remifentanil was infused subcutaneously at the moment of surgical incision over a period of 30 min), and group IR (mice underwent a surgical incision and remifentanil). Paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL) tests were performed 24 h before the operation and 2, 6, 24, and 48 h after the operation. The specimens were collected after behavioral testings at 48 h. The expressions of Mor and NRSF in mice's PAG neurons were determined by Western blot. RESULTS: CONCLUSION: Intraoperative infusion of remifentanil induces postoperative hyperalgesia in mouse models, accompanied with decreased expressions of Mor and increased of NRSF level in PAG neurons, which may be involved in remifentanil induced hyperalgesia.
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Authors | Mingjian Kong, Linyu Shi, Yu Zhou, Jianhua He, Wei Zhang, Xiaoping Gu, Juan Zhang, Zhengliang Ma |
Journal | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
(Zhong Nan Da Xue Xue Bao Yi Xue Ban)
Vol. 39
Issue 9
Pg. 901-6
(Sep 2014)
ISSN: 1672-7347 [Print] China |
PMID | 25269492
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Piperidines
- RE1-silencing transcription factor
- Receptors, Opioid, mu
- Repressor Proteins
- Remifentanil
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Topics |
- Animals
- Disease Models, Animal
- Hyperalgesia
(chemically induced)
- Mice
- Pain, Postoperative
- Periaqueductal Gray
(drug effects, metabolism)
- Piperidines
(administration & dosage)
- Receptors, Opioid, mu
(metabolism)
- Remifentanil
- Repressor Proteins
(metabolism)
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