Abstract | PURPOSE OF THE STUDY: MATERIALS AND METHODS: Nanoparticles were prepared by desolvation technique and coated with polysorbate 80. Ethanol, glutaraldehyde, and mannitol were used as desolvating, cross linking agent, and cryoprotectant, respectively. Drug to polymer ratio was chosen at five levels from 1:2, 1:3, 1:4, 1:5, and 1:6 (by weight). The formulated nanoparticles were characterized for Fourier Transform Infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC) studies, entrapment efficiency, particle size, surface charge, surface morphology, in vitro drug release, release kinetics, stability studies, and biodistribution studies. RESULTS AND MAJOR CONCLUSION: The particle size of the prepared formulations was found below 250nm with narrow size distribution, spherical in shape and showed good entrapment efficiency (45.62-72.49%). The in vitro drug release indicated biphasic release and its data were fitted to release kinetics models and release pattern was Fickian diffusion controlled release profile. The prepared nanoparticles increased efavirenz delivery into various organs by several fold in comparison with the free drug.
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Authors | Josephine Leno Jenita, Vijaya Chocalingam, Barnabas Wilson |
Journal | International journal of pharmaceutical investigation
(Int J Pharm Investig)
Vol. 4
Issue 3
Pg. 142-8
(Jul 2014)
ISSN: 2230-973X [Print] India |
PMID | 25126528
(Publication Type: Journal Article)
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