Abstract | BACKGROUND: Staphylococcus aureus has been implicated in the pathogenesis of adult hand/foot dermatitis. OBJECTIVE: METHODS: Adult subjects with moderate to very severe hand/foot dermatitis had twice-daily topical application of clobetasol propionate 0.05% foam to hands/feet for 14 days and were randomized to apply either retapamulin 1% ointment or vehicle ointment twice daily to hands/feet and nares for five days. RESULTS: Seventy-three percent of subjects in the retapamulin/ clobetasol group were clear/almost clear at Day 15 compared to 47 percent of subjects in the vehicle/ clobetasol group (p-value of 0.04). The percentage of subjects who had both negative skin and nares cultures and were clear/almost clear was also statistically significant in favor of the retapamulin/ clobetasol group at Day 15 (p-value of 0.05). LIMITATIONS: Sample size, study population. CONCLUSION:
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Authors | Madelaine Haddican, Rita V Linkner, Giselle Singer, Shelbi C Jim, Matthew Gagliotti, Gary Goldenberg |
Journal | The Journal of clinical and aesthetic dermatology
(J Clin Aesthet Dermatol)
Vol. 7
Issue 7
Pg. 32-6
(Jul 2014)
ISSN: 1941-2789 [Print] United States |
PMID | 25053981
(Publication Type: Journal Article)
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