Abstract | BACKGROUND: AIMS: The aim of this study was to examine the impact of different classes of antihypertensive agent on stroke outcome using data from the ChinaQUEST study, a prospective, hospital-based stroke registry undertaken across 62 hospitals in China. METHODS: Logistic regression analysis was used to determine the comparative associations of different antihypertensive medications when initiated in-hospital post- stroke on the following poor outcomes in stroke survivors at three- and 12 months post- stroke: (1) death and dependency, based on modified Rankin Scale scores 3-5; (2) death; and (3) dependency. RESULTS: Of the 6416 patients with baseline data, 3986 (62%) were on at least one antihypertensive agent. After adjustment for baseline characteristics and concomitant therapies, there were no differences in outcomes between therapies at three- and 12 months, but at 12 months, calcium channel blocker use was associated with reduced risks of death/dependency (odds ratio 0·78, P = 0·001) and death (odds ratio 0·66, P < 0·001). In addition, angiotensin-converting enzyme inhibitor/ angiotensin II receptor antagonist use was associated with reduced risk of death (odds ratio 0·76, P = 0·009), whereas both beta-blockers and diuretics were shown to increase the risk of death/dependency and death but had no effect on the risk of dependency. CONCLUSION:
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Authors | Emma L Heeley, Jade W Wei, Ji-Guang Wang, Hisatomi Arima, Yining Huang, Lawrence K S Wong, Craig S Anderson, ChinaQUEST Investigators |
Journal | International journal of stroke : official journal of the International Stroke Society
(Int J Stroke)
Vol. 9 Suppl A100
Pg. 113-8
(Oct 2014)
ISSN: 1747-4949 [Electronic] United States |
PMID | 25042450
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 World Stroke Organization. |
Chemical References |
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors
- Antihypertensive Agents
- Calcium Channel Blockers
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Topics |
- Angiotensin Receptor Antagonists
(therapeutic use)
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Antihypertensive Agents
(classification, therapeutic use)
- Calcium Channel Blockers
(therapeutic use)
- China
- Databases, Factual
(ethics)
- Female
- Humans
- Logistic Models
- Male
- Stroke
(drug therapy, mortality)
- Survival Analysis
- Time Factors
- Treatment Outcome
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