Ischemia/reperfusion injury (IRI) can lead to cellular and, eventually, organ dysfunction, with the liver being one of the most frequently affected organs.
Melatonin, a molecule that has notable
antioxidant and anti-inflammatory properties, has been shown to protect against hepatic IRI. The purpose of this review is to summarize the protective effects of
melatonin on hepatic IRI. The review initially summarizes the
antioxidant properties of
melatonin. We then discuss the protective effects of
melatonin against endothelial and
mitochondrial dysfunction. Thereafter, we introduce some information covering
melatonin-related signaling pathways, including
heme oxygenase-1 (HO-1),
toll-like receptor (TLR),
c-Jun N-terminal kinase (JNK), and so on. Furthermore, the clinical application of
melatonin to hepatic diseases is considered. Finally, the safety of
melatonin is evaluated. Taken together, the information compiled in this review will serve as a comprehensive reference regarding the pharmacological benefits of
melatonin on hepatic IRI, aid in the design of future experimental research, and promote
melatonin as a new therapeutic target.