Inverse association of plasma vanadium levels with newly diagnosed type 2 diabetes in a Chinese population.

Abstract

Vanadium compounds have been proposed to have beneficial effects on the pathogenesis and complications of type 2 diabetes. Our objective was to evaluate the association between plasma vanadium levels and type 2 diabetes. We performed a case-control study involving 1,598 Chinese subjects with or without newly diagnosed type 2 diabetes (December 2004-December 2007). Cases and controls were frequency-matched by age and sex. Plasma vanadium concentrations were measured and compared between groups. Analyses showed that plasma vanadium concentrations were significantly lower in cases with newly diagnosed type 2 diabetes than in controls (P = 0.001). Mean plasma vanadium levels in participants with and without diabetes were 1.0 μg/L and 1.2 μg/L, respectively. Participants in the highest quartile of plasma vanadium concentration had a notably lower risk of newly diagnosed type 2 diabetes (odds ratio = 0.26, 95% confidence interval: 0.19, 0.35; P < 0.001), compared with persons in the lowest quartile. The trend remained significant after adjustment for known risk factors and in further stratification analyses. Our results suggested that plasma vanadium concentrations were inversely associated with newly diagnosed type 2 diabetes in this Chinese population.

• Authors: Xia Wang, Taoping Sun, Jun Liu, Zhilei Shan, Yilin Jin, Sijing Chen, Wei Bao, Frank B Hu, Liegang Liu
• Journal: American journal of epidemiology (Am J Epidemiol) Vol. 180 Issue 4 Pg. 378-84 (Aug 15 2014) ISSN: 1476-6256 [Electronic] United States
• PMID: 25005791 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author 2014. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• Vanadium

Topics

• Case-Control Studies
• Chi-Square Distribution
• China (epidemiology)
• Diabetes Mellitus, Type 2 (blood, epidemiology, etiology)
• Female
• Humans
• Logistic Models
• Male
• Middle Aged
• Odds Ratio
• Risk Factors
• Vanadium (blood)