Vitamin E-diffused highly cross-linked UHMWPE particles induce less osteolysis compared to highly cross-linked virgin UHMWPE particles in vivo.

Abstract

Recent in vitro findings suggest that UHMWPE wear particles containing vitamin E (VE) may have reduced biologic activity and decreased osteolytic potential. We hypothesized that particles from VE-stabilized, radiation cross-linked UHMWPE would cause less osteolysis in a murine calvarial bone model when compared to virgin gamma irradiated cross-linked UHMWPE. Groups received equal amount of particulate debris overlaying the calvarium for 10 days. Calvarial bone was examined using high resolution micro-CT and histomorphometric analyses. There was a statistically significant difference between virgin (12.2%±8%) and VE-UHMWPE (3%±1.4%) groups in regards to bone resorption (P=0.005) and inflammatory fibrous tissue overlaying the calvaria (0.48 vs. 0.20, P<0.0001). These results suggest that VE-UHMWPE particles have reduced osteolytic potential in vivo when compared to virgin UHMWPE.

• Authors: David A Bichara, Erik Malchau, Nanna H Sillesen, Selami Cakmak, G Petur Nielsen, Orhun K Muratoglu
• Journal: The Journal of arthroplasty (J Arthroplasty) Vol. 29 Issue 9 Suppl Pg. 232-7 (Sep 2014) ISSN: 1532-8406 [Electronic] United States
• PMID: 24998319 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Polyethylenes
• ultra-high molecular weight polyethylene
• Vitamin E

Topics

• Animals
• Disease Models, Animal
• Gamma Rays
• Male
• Mice, Inbred C57BL
• Microscopy, Electron, Scanning
• Osteolysis (etiology, prevention & control)
• Particle Size
• Polyethylenes (pharmacology)
• Random Allocation
• Skull (diagnostic imaging, pathology)
• Vitamin E (pharmacology)
• X-Ray Microtomography