Low-protein diet for diabetic nephropathy.

Abstract

Diabetic nephropathy is the leading cause of progressive kidney disease, leading to end-stage renal disease and renal replacement therapy. Angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers have been considered effective at slowing the progression of kidney function deterioration. However, these drugs cannot sufficiently halt the progression of nephropathy to the extent that is required. A low-protein diet (LPD) is believed to be a nutritional intervention that may slow kidney disease progression. In fact, preclinical animal experiments have demonstrated excellent renoprotective effects of an LPD. However, in human clinical trials, analyses of the effects of protein restriction on diabetic nephropathy have not yet revealed consistently positive outcomes of this nutritional intervention. In this review, we analyze the potential renoprotective effects of an LPD on diabetic nephropathy and summarize the outcomes of clinical trials that have systematically investigated the efficacy of an LPD in diabetic nephropathy. In addition, we discuss some potential approaches associated with nutritional interventions to combat progressive kidney disease.

• Authors: Toshiki Otoda, Keizo Kanasaki, Daisuke Koya
• Journal: Current diabetes reports (Curr Diab Rep) Vol. 14 Issue 9 Pg. 523 ( 2014) ISSN: 1539-0829 [Electronic] United States
• PMID: 24986448 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers

Topics

• Animals
• Biomarkers (metabolism)
• Caloric Restriction
• Diabetic Nephropathies (diet therapy)
• Diet, Carbohydrate-Restricted
• Diet, Protein-Restricted (adverse effects)
• Humans
• Renin-Angiotensin System