Acute lymphocytic leukemia with superimposed invasive aspergillosis and pneumopericardium successfully treated with voriconazole.

Abstract

We present a 47-year-old man with acute lymphocytic leukemia with a pericardial friction rub heralding pericardial aspergillosis. The clinical course was complicated by pneumopericardium, likely secondary to a direct connection between the lung parenchyma and the pericardial space. Bronchoalveolar lavage cultures returned positive for methicillin-resistant Staphylococcus aureus and Aspergillus niger. Combination voriconazole and vancomycin resulted in symptomatic improvement within 2 weeks of hospitalization.

• Authors: Carlos L Alviar, Bryan Doherty, Muthiah Vaduganathan
• Journal: Proceedings (Baylor University. Medical Center) (Proc (Bayl Univ Med Cent)) Vol. 27 Issue 3 Pg. 250-2 (Jul 2014) ISSN: 0899-8280 [Print] United States
• PMID: 24982579 (Publication Type: Case Reports)