Therapy for systemic juvenile rheumatoid arthritis with gamma-interferon: a pilot study of nine patients.

Abstract

Nine severely ill patients with a confirmed diagnosis of systemic juvenile rheumatoid arthritis were treated with recombinant gamma-interferon (gamma-IFN) in addition to the therapy they were previously receiving for their disease. Improvements in clinical symptoms were noted in 7 of the patients, and median laboratory values also showed a marked improvement after gamma-IFN treatment. A relapse occurred in 1 patient. The results of this study should stimulate further research on the use of gamma-IFN in systemic juvenile rheumatoid arthritis, particularly in determining the appropriate effective dosage.

• Authors: W Pernice, L Schuchmann, J Dippell, J Suschke, P Vogel, H Truckenbrodt, F Schindera, C Humburg, J Brzoska
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 32 Issue 5 Pg. 643-6 (May 1989) ISSN: 0004-3591 [Print] United States
• PMID: 2497750 (Publication Type: Journal Article)

Chemical References

• Recombinant Proteins
• Interferon-gamma

Topics

• Arthritis, Juvenile (pathology, therapy)
• Child
• Child, Preschool
• Humans
• Interferon-gamma (therapeutic use)
• Pilot Projects
• Recombinant Proteins