Abstract | OBJECTIVE: Observations in both animal models of arthritis and patients with rheumatoid arthritis (RA) suggest a role for dopamine and its receptors in RA. Because synovial fibroblasts (SFs) contribute to inflammation and joint destruction in RA, the aim of this study was to investigate dopaminergic pathways in SFs obtained from patients with RA and, for comparison, in SFs from patients with osteoarthritis (OA) undergoing knee joint replacement surgery. METHODS: RESULTS: CONCLUSION: SFs from patients with RA and patients with OA show a dopaminergic phenotype. The expression of D1-like dopamine receptors was higher in RASFs, and this increased expression may lead to antiinflammatory effects, as demonstrated by the expression of IL-8. Studies in animal models and patients with RA are needed to assess the therapeutic potential of endogenous, local production of dopamine in synoviocytes.
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Authors | Silvia Capellino, Marco Cosentino, Alessandra Luini, Raffaella Bombelli, Torsten Lowin, Maurizio Cutolo, Franca Marino, Rainer H Straub |
Journal | Arthritis & rheumatology (Hoboken, N.J.)
(Arthritis Rheumatol)
Vol. 66
Issue 10
Pg. 2685-93
(Oct 2014)
ISSN: 2326-5205 [Electronic] United States |
PMID | 24965369
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 by the American College of Rheumatology. |
Chemical References |
- Dopamine Plasma Membrane Transport Proteins
- Interleukin-6
- Interleukin-8
- Receptors, Dopamine
- Tissue Inhibitor of Metalloproteinase-1
- Tissue Inhibitor of Metalloproteinase-2
- Matrix Metalloproteinase 3
- Dopamine
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Topics |
- Arthritis, Rheumatoid
(metabolism)
- Cells, Cultured
- Dopamine
(pharmacology)
- Dopamine Plasma Membrane Transport Proteins
(metabolism)
- Fibroblasts
(drug effects, metabolism)
- Humans
- Interleukin-6
(metabolism)
- Interleukin-8
(metabolism)
- Matrix Metalloproteinase 3
(metabolism)
- Osteoarthritis
(metabolism)
- Receptors, Dopamine
(metabolism)
- Synovial Membrane
(drug effects, metabolism)
- Tissue Inhibitor of Metalloproteinase-1
(metabolism)
- Tissue Inhibitor of Metalloproteinase-2
(metabolism)
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