Abstract | OBJECTIVE: DESIGN: Randomized placebo-controlled trial. SETTING: Tertiary-care teaching hospital. PARTICIPANTS: INTERVENTION: Neonates were randomized to receive either oral zinc sulfate (10 mg/d) or placebo for 7 days. MAIN OUTCOME MEASURES: Primary: total serum bilirubin levels at 48 (±12) h, 96 (±12) h and 144 (±12) h after intervention. Secondary: duration of phototherapy, and serum zinc and copper levels. RESULTS: Baseline mean (SD) total serum bilirubin levels were 14.8 (3.8) and 14.4 (3.5) mg/dL in zinc and placebo groups, respectively. No significant differences were observed in total bilirubin levels between the two groups after the intervention. Mean (SD) total serum bilirubin levels in zinc and placebo groups were 13.9 (2.5) vs. 13.4 (1.9) mg/dL (mean difference 0.566; 95% CI -0.535, 1.668, P=0.038) at 48 h, 13.1 (2.7) vs. 12.8 (2.3) mg/dL (mean difference 0.234; 95% CI -1.011, 1.479, P =0.708) at 96 h and 8.0 (2.0) vs. 8.6 (1.2) mg/dL (mean difference -0.569, 95% CI -1.382, 0.242, P=0.166) at 144 h. Although the mean duration of phototherapy in the zinc group was less by 21.3 h (95% CI 11.6, 30.9, P=0.052), the difference was not significant. Post-intervention, serum zinc levels were significantly higher in the zinc-supplemented group while serum copper levels were comparable between the two groups. CONCLUSIONS:
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Authors | Ashok Kumar, Narendra Kumar Bagri, Sriparna Basu, Ravi Kumar Asthana |
Journal | Indian pediatrics
(Indian Pediatr)
Vol. 51
Issue 5
Pg. 375-8
(May 2014)
ISSN: 0974-7559 [Electronic] India |
PMID | 24953578
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Placebos
- Zinc Sulfate
- Bilirubin
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Topics |
- Adult
- Bilirubin
(blood)
- Female
- Humans
- Hyperbilirubinemia, Neonatal
(blood, drug therapy, epidemiology)
- Infant, Newborn
- Male
- Phototherapy
- Placebos
- Treatment Outcome
- Young Adult
- Zinc Sulfate
(administration & dosage, therapeutic use)
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