HLA genotypes and rubella vaccine immune response: additional evidence.

Abstract

Recent population-based studies have demonstrated the genetic heritability of rubella vaccine response and assessed that the HLA system may explain about 20% of the inter-individual variance in humoral immune response to this vaccine. Our earlier studies compared HLA allelic associations with rubella vaccine-specific antibodies between two smaller cohorts of healthy Rochester, MN, children (346 and 396 subjects) after two doses of rubella-containing vaccine. This study found that specific HLA alleles were consistently associated with rubella-specific antibody titers (B*27:05, DPA1*02:01, and DPB1*04:01 alleles). The current study examined HLA associations in an independent larger cohort of 1012 healthy San Diego, CA, subjects (age 19-40 years) after rubella vaccine in order to replicate our previous findings in the Rochester subjects. Two HLA associations of comparable magnitudes were consistently observed between B*27:05 (median NT50 Rochester cohort 48.9, p=0.067; San Diego cohort 54.8, p=0.047) and DPB1*04:01 (median NT50 Rochester cohort 61.6, p<0.001; San Diego cohort 70.8, p=0.084) alleles and rubella virus-neutralizing antibody titers. Additional HLA alleles resulted in consistent effects on IL-6 production in both cohorts, but did not meet criteria for statistical significance. Our data suggest these HLA alleles play a role in rubella vaccine-induced immunity and provide the basis for future studies that may explain the mechanism(s) by which these HLA polymorphisms affect immune responses to rubella vaccine.

• Authors: Inna G Ovsyannikova, V Shane Pankratz, Beth R Larrabee, Robert M Jacobson, Gregory A Poland
• Journal: Vaccine (Vaccine) Vol. 32 Issue 33 Pg. 4206-13 (Jul 16 2014) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 24837503 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Antibodies, Neutralizing
• Antibodies, Viral
• HLA-A Antigens
• HLA-A*31:01 antigen
• HLA-B*27:05 antigen
• HLA-B27 Antigen
• HLA-DP beta-Chains
• HLA-DPB1*04:01 antigen
• Rubella Vaccine

Topics

• Adolescent
• Adult
• Antibodies, Neutralizing (blood)
• Antibodies, Viral (blood)
• Child
• Female
• Genotype
• HLA-A Antigens (genetics)
• HLA-B27 Antigen (genetics)
• HLA-DP beta-Chains (genetics)
• Humans
• Immunity, Humoral
• Male
• Middle Aged
• Rubella Vaccine (therapeutic use)
• Young Adult