Variations in mitochondrial tRNA(Thr) gene may not be associated with coronary heart disease.

Abstract

Mutations in mitochondrial tRNAThr gene were recently reported to be associated with coronary heart disease. These mutations, such as T15889C, G15927A, G15930A and A15951G, were claimed to be pathogenic. To examine whether these mutations contributed to the genetic susceptibility to coronary heart disease, we analyzed the conservation index of these mutations between different species. In particular, reports concerning the role of the G15927A mutation was the most controversial. Therefore, based on the previous and this study, we conducted that mutations in mitochondrial tRNAThr gene may not be associated with coronary heart disease.

• Authors: Hui Pei, Qian Peng, Chao Lan, Bao Chi Liu
• Journal: Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis (Mitochondrial DNA A DNA Mapp Seq Anal) Vol. 27 Issue 1 Pg. 565-8 ( 2016) ISSN: 2470-1408 [Electronic] England
• PMID: 24708135 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Mitochondrial
• RNA, Transfer, Thr

Topics

• Base Sequence
• Coronary Artery Disease (genetics)
• DNA, Mitochondrial (genetics)
• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• Molecular Sequence Data
• Mutation (genetics)
• Nucleic Acid Conformation
• Phylogeny
• RNA, Transfer, Thr (genetics)
• Sequence Alignment