Advanced breast angiosarcoma completely responding to gemcitabine-containing chemotherapy.

Abstract

BACKGROUND:

For patients with anthracycline-resistant metastatic angiosarcoma, there is currently no available standard for second-line therapy, and a need exists for novel effective regimens to improve response rates.

CASE REPORT:

We report here on a case of a primary angiosarcoma of both breasts in a 34-year-old woman presenting with lung metastases. Upon completion of 3 cycles of the MAID regimen (mesna, adriamycin, ifosfamide, dacarbazine), computed tomography showed disease progression. Subsequently, a second-line chemotherapy was started using the GVP regimen (gemcitabine, vincristine, cisplatin). Complete response of the lung metastases was achieved after 6 cycles of treatment.

CONCLUSION:

In the absence of an effective therapy among patients with anthracycline-resistant metastatic breast angiosarcoma, a GVP chemotherapy regimen can be performed as a selective option.

• Authors: Zhi-Guo Luo, Qian Wang, Wei Peng, Xi-Chun Hu, Xiao-Nan Hong
• Journal: Breast care (Basel, Switzerland) (Breast Care (Basel)) Vol. 7 Issue 5 Pg. 414-6 (Oct 2012) ISSN: 1661-3791 [Print] Switzerland
• PMID: 24647783 (Publication Type: Case Reports)