Abstract |
During an outbreak of methanol poisonings in the Czech Republic in 2012, we were able to study methanol and formate elimination half-lives during intermittent hemodialysis (IHD) and continuous veno-venous hemodialysis/ hemodiafiltration ( CVVHD/HDF) and the relative impact of dialysate and blood flow rates on elimination. Data were obtained from 11 IHD and 13 CVVHD/HDF patients. Serum methanol and formate concentrations were measured by gas chromatography and an enzymatic method. The groups were relatively comparable, but the CVVHD/HDF group was significantly more acidotic (mean pH 6.9 vs. 7.1 IHD). The mean elimination half-life of methanol was 3.7 and formate 1.6 h with IHD, versus 8.1 and 3.6 h, respectively, with CVVHD/HDF (both significant). The 54% greater reduction in methanol and 56% reduction in formate elimination half-life during IHD resulted from the higher blood and dialysate flow rates. Increased blood and dialysate flow on the CVVHD/HDF also increased elimination significantly. Thus, IHD is superior to CVVHD/HDF for more rapid methanol and formate elimination, and if CVVHD/HDF is the only treatment available then elimination is greater with greater blood and dialysate flow rates.
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Authors | Sergey Zakharov, Daniela Pelclova, Tomas Navratil, Jaromir Belacek, Ivana Kurcova, Ondrej Komzak, Tomas Salek, Jiri Latta, Radovan Turek, Robert Bocek, Cyril Kucera, Jaroslav A Hubacek, Zdenka Fenclova, Vit Petrik, Martin Cermak, Knut Erik Hovda |
Journal | Kidney international
(Kidney Int)
Vol. 86
Issue 1
Pg. 199-207
(Jul 2014)
ISSN: 1523-1755 [Electronic] United States |
PMID | 24621917
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidotes
- Formates
- Hemodialysis Solutions
- formic acid
- Methanol
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Topics |
- Adult
- Aged
- Antidotes
(therapeutic use)
- Blood Flow Velocity
- Czech Republic
- Female
- Formates
(blood)
- Half-Life
- Hemodiafiltration
(methods)
- Hemodialysis Solutions
- Humans
- Hydrogen-Ion Concentration
- Male
- Methanol
(blood, poisoning)
- Middle Aged
- Prospective Studies
- Renal Dialysis
(methods)
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