MR-guided laser-induced thermotherapy (LITT) in patients with liver metastases of uveal melanoma.

Abstract

PURPOSE:

Evaluation of the local tumour control rate and survival data for magnetic resonance (MR) imaging-guided laser ablation of uveal malignant melanoma liver metastases by using laser-induced interstitial thermotherapy (LITT).

MATERIALS AND METHODS:

The LITT was performed in 18 patients with liver metastases (n = 44) from uveal malignant melanoma. All patients tolerated this intervention well. With the Kaplan-Meier method, the survival rates were calculated. Indications for the procedure were defined for patients with no more than five metastases, none of which were larger than 5 cm in diameter: The Indication for LITT treatment were recurrent liver metastases after partial liver resection (22%), locally non-resectable tumours (17%) or metastases in both liver lobes (61%).

RESULTS:

The mean survival rate for all treated patients was 3.6 years (95% CI: 2.19, 5.06). We started the calculation on the date of diagnosis of the metastases treated with LITT. The median survival was 1.83 years; 1-year survival, 88%; 3-year survival 47%, 5-year survival 17%. Calculated after the first LITT treatment the median survival was 2.8 years (95% CI: 1.0, 5.0). 10 patients were treated by transarterial chemoembolization before LITT.

CONCLUSION:

MR-guided LITT treatment shows a high local tumour control and survival rates in patients with liver metastases of uveal malignant melanoma.

• Authors: K Eichler, S Zangos, T Gruber-Rouh, T J Vogl, M G Mack
• Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 28 Issue 12 Pg. 1756-60 (Dec 2014) ISSN: 1468-3083 [Electronic] England
• PMID: 24593299 (Publication Type: Journal Article)
• Copyright: © 2014 European Academy of Dermatology and Venereology.

Topics

• Adult
• Aged
• Female
• Humans
• Hyperthermia, Induced
• Liver Neoplasms (secondary, therapy)
• Magnetic Resonance Imaging
• Male
• Melanoma (pathology, therapy)
• Middle Aged
• Survival Rate
• Uveal Neoplasms (pathology, therapy)