Abstract | INTRODUCTION: MATERIAL AND METHODS: We studied 54 patients with sickle cell disease who underwent partial splenectomy in childhood from 1986 until 2011 at the Institute of Hematology and Immunology. They were compared with 54 non-splenectomized patients selected by random sampling with similar characteristics. RESULTS: Partial splenectomy was performed at a mean age of 4.1 years, with a higher frequency in homozygous hemoglobin S (70.4%), and the most common cause was recurrent splenic sequestration crisis. The most common postoperative complications were fever of unknown origin (14.8%) and acute chest syndrome (11.1%). After splenectomy there was a significant increase in leukocytes, neutrophils, and platelets, the latter two parameters remained significantly elevated when compared with non-splenectomized patients. There was no difference in the incidence of clinical events, except hepatic sequestration, which was more common in splenectomized patients. CONCLUSION: Partial splenectomy was a safe procedure in patients with sickle cell disease. There were no differences in the clinical picture in children splenectomized and non-splenectomized except the greater frequency of hepatic sequestration crisis in the first group.
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Authors | A I Gutiérrez Díaz, E Svarch, A Arencibia Núñez, V Sabournin Ferrier, S Machín García, A Menendez Veitía, L Ramón Rodriguez, J Serrano Mirabal, T García Peralta, L G López Martin |
Journal | Anales de pediatria (Barcelona, Spain : 2003)
(An Pediatr (Barc))
Vol. 82
Issue 4
Pg. 228-34
(Apr 2015)
ISSN: 1695-9531 [Electronic] Spain |
Vernacular Title | Esplenectomía parcial en pacientes con drepanocitosis. |
PMID | 24582518
(Publication Type: Comparative Study, Journal Article, Observational Study)
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Copyright | Copyright © 2013 Asociación Española de Pediatría. Published by Elsevier España, S.L.U. All rights reserved. |
Topics |
- Adolescent
- Adult
- Anemia, Sickle Cell
(complications)
- Child
- Child, Preschool
- Female
- Humans
- Infant
- Male
- Retrospective Studies
- Splenectomy
(methods)
- Splenic Diseases
(etiology, surgery)
- Young Adult
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