trans-11 18:1 vaccenic acid (TVA) has a direct anti-carcinogenic effect on MCF-7 human mammary adenocarcinoma cells.

Abstract

Trans vaccenic acid (TVA; trans-11 18:1) is a positional and geometric isomer of oleic acid and it is the predominant trans isomer found in ruminant fats. TVA can be converted into cis-9, trans-11 conjugated linoleic acid (c9, t11-CLA), a CLA isomer that has many beneficial effects, by stearoyl CoA desaturase 1 (SCD1) in the mammary gland. The health benefits associated with CLA are well documented, but it is unclear whether trans fatty acids (TFAs) from ruminant products have healthy effects. Therefore, the effects of TVA on the proliferation of MCF-7 human breast adenocarcinoma cells and MCF-10A human breast epithelial cells were investigated in the present study. Results showed that TVA inhibited the proliferation of MCF-7 cells but not MCF-10A cells by down-regulating the expression of Bcl-2 as well as procaspase-9. In addition, the suppressive effect of TVA was confirmed in SCD1-depleted MCF-7 cells. Our results suggested that TVA exerts a direct anti-carcinogenic effect on MCF-7 cells. These findings provided a better understanding of the research on the anti-carcinogenic effects of TVA and this may facilitate the manufacture of TVA/c9, t11-CLA fortified ruminant products.

• Authors: Ji-Na Lim, Jin-Ju Oh, Tao Wang, Jae-Sung Lee, Sang-Hun Kim, Yoon-Jin Kim, Hong-Gu Lee
• Journal: Nutrients (Nutrients) Vol. 6 Issue 2 Pg. 627-36 (Feb 10 2014) ISSN: 2072-6643 [Electronic] Switzerland
• PMID: 24518825 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• BAX protein, human
• Oleic Acids
• RNA, Messenger
• RNA, Small Interfering
• bcl-2-Associated X Protein
• SCD1 protein, human
• Stearoyl-CoA Desaturase
• CASP9 protein, human
• Caspase 9
• 11-octadecenoic acid

Topics

• Adenocarcinoma (metabolism, pathology)
• Anticarcinogenic Agents (pharmacology)
• Apoptosis (drug effects)
• Breast Neoplasms (metabolism, pathology)
• Caspase 9 (genetics, metabolism)
• Cell Proliferation (drug effects)
• Down-Regulation
• Epithelial Cells (drug effects, metabolism)
• Female
• Humans
• MCF-7 Cells
• Oleic Acids (pharmacology)
• RNA, Messenger (genetics)
• RNA, Small Interfering (genetics, metabolism)
• Stearoyl-CoA Desaturase (genetics, metabolism)
• bcl-2-Associated X Protein (genetics, metabolism)