Dendritic cell neurofibroma with pseudorosettes: a clinicopathologic and immunohistochemical study of 5 intraoral cases.

Abstract

OBJECTIVE:

We report cases of dendritic cell neurofibroma with pseudorosettes (DCNP) presenting in the oral cavity and discuss clinicopathologic and immunohistochemical features that differentiate this from other benign peripheral nerve sheath tumors.

STUDY DESIGN:

DCNPs were identified over a 2-year period, and history and histopathologic features were reviewed. Common nerve sheath tumors from the same period were identified and compared.

RESULTS:

Five intraoral cases of DCNP presented in 2 men and 3 women, with a median age of 59 years. Three presented on the buccal mucosa, and 2 presented on the tongue. Each exhibited a biphasic population of cells with pseudorosettes and strong CD57 positivity.

CONCLUSIONS:

With 31 cases of DCNP reported, the most common site of occurrence is now the head and neck region. DCNPs exhibit a characteristic biphasic population of cells and strong CD57 positivity. Pathologists should consider this diagnosis when confronted with unusual neural lesions.

• Authors: Mark A Lerman, Chia-Cheng Li, Sook-Bin Woo
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 117 Issue 2 Pg. 221-6 (Feb 2014) ISSN: 2212-4411 [Electronic] United States
• PMID: 24439917 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers, Tumor
• CD57 Antigens

Topics

• Adult
• Aged
• Biomarkers, Tumor (analysis)
• CD57 Antigens (analysis)
• Dendritic Cells (pathology)
• Female
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Mouth Neoplasms (pathology)
• Neurofibroma (pathology)
• Tongue Neoplasms (pathology)