New autoantibodies and their clinical associations in juvenile myositis - a systematic review.

Abstract

BACKGROUND:

Novel autoantibodies targeting intracellular proteins are recently detected in patients with idiopathic inflammatory myopathies (IIMs).

OBJECTIVE:

To evaluate the prevalence of these myositis-specific antibodies (MSAs) in juvenile IIMs (JIIMs) and their association with clinical characteristics and disease course.

METHODS:

A systematic literature search was carried out to identify all studies concerning these novel MSAs (p155/140, p140, CADM-140, SAE and 200/100) in patients with JIIMs.

RESULTS:

A total of 1003 references were identified, of which 118 were selected for detailed analysis and 13 included in the final review.

CONCLUSIONS:

The anti-p155/140, the anti-p140 and the anti-CADM-140 seem to be useful markers for define distinct clinical subsets and for predicting prognosis of JIIMs. Further studies are needed to clarify the importance of anti 200/100 and anti-SAE in juvenile myositis.

• Authors: Daniela Peixoto, José Costa, Marta Ferretti, Clara Malattia, Alberto Martini
• Journal: Acta reumatologica portuguesa (Acta Reumatol Port) 2013 Oct-Dec Vol. 38 Issue 4 Pg. 234-41 ISSN: 2184-8777 [Electronic] Portugal
• PMID: 24435027 (Publication Type: Journal Article, Review, Systematic Review)

Chemical References

• Autoantibodies

Topics

• Autoantibodies (immunology)
• Dermatomyositis (immunology)
• Humans