N-acetyl-D-mannosamine treatment alleviates age-related decline in place-learning ability in dogs.

Abstract

This study aimed to investigate the therapeutic effects of N-acetyl-D-mannosamine (ManNAc) on age-related cognitive dysfunction in dogs. ManNAc was administered to 5 dogs with low cognitive levels for 2 months, and the cognitive ability and active-resting cycle were periodically assessed for improvement. ManNAc treatment significantly reduced the number of error trials in the place-learning test, especially in the first month of administration. Three ManNAc-treated dogs also showed improvement in the active-resting cycle. In conclusion, ManNAc treatment appears to alleviate age-related cognitive dysfunction.

• Authors: Miho Nagasawa, Aki Shimozawa, Kazutaka Mogi, Takefumi Kikusui
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 76 Issue 5 Pg. 757-61 (May 2014) ISSN: 1347-7439 [Electronic] Japan
• PMID: 24430654 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hexosamines
• N-acetylmannosamine

Topics

• Aging (drug effects, physiology)
• Analysis of Variance
• Animals
• Cross-Over Studies
• Dogs
• Female
• Hexosamines (pharmacology)
• Japan
• Male
• Neuropsychological Tests
• Spatial Learning (drug effects, physiology)