Abstract | OBJECTIVE: To evaluate the efficacy and tolerability of the fixed combination of Latanoprost/ Timolol versus Dorzolamide/ Timolol in the treatment of patients with elevated intraocular pressure (IOP). METHODS: A comprehensive literature meta-analysis was performed according to the Cochrane Collaboration methodology to identify randomized clinical trials comparing latanoprost/ timolol FC (FCLT) with dorzolamide/ timolol ( FCDT) in patients with elevated IOP. The efficacy estimates were measured by the weight mean difference (WMD) for the IOP reduction (IOPR) from baseline to end point, including the diurnal mean IOPR, 8 AM IOPR, 12 PM IOPR, and 4 PM IOPR. The tolerability estimates were measured by RR for adverse events. All outcomes were reported with a 95% confidence interval (CI). The data were synthesized by Stata 12.0 SE for Windows. RESULTS: Eight studies involving 841 patients (841 eyes) were included in the meta-analysis. With a WMD of IOPR in the diurnal mean of 0.16 mmHg (95% CI, -0.31 to 0.63), the FCLT was as effective as FCDT in lowering IOP in patients with elevated IOP (P = 0.51). The WMDs of IOPR were 0.58 mmHg (95% CI: -0.002 to 1.17) at 8 AM, -0.07 mmHg (95% CI: -0.50 to 0.36) at 12 PM, and 0.41 mmHg (95% CI: -0.18 to 1.00) at 4 PM, and there were no significant difference between FCLT and FCDT. FCLT was associated with a significantly lower incidence of eye pain, bitter taste, and irritation/stinging than FCDT, with pooled RRs of 0.34 (95% CI: 0.14 to 0.82), 0.06 (95% CI:0.008 to 0.42), and 0.35 (95% CI: 0.14 to 0.85), respectively. CONCLUSION: FCLT was associated with equivalent efficacy in IOP lowering comparing with FCDT. However, FCLT was better tolerated than FCDT.
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Authors | Miao He, Wei Wang, Wenyong Huang |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 12
Pg. e83606
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 24349536
(Publication Type: Comparative Study, Journal Article, Meta-Analysis, Review)
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Chemical References |
- Antihypertensive Agents
- Prostaglandins F, Synthetic
- Sulfonamides
- Thiophenes
- Latanoprost
- Timolol
- dorzolamide
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Topics |
- Antihypertensive Agents
(adverse effects, therapeutic use)
- Drug Tolerance
- Female
- Humans
- Intraocular Pressure
(drug effects)
- Latanoprost
- Male
- Ocular Hypertension
(drug therapy, physiopathology)
- Prostaglandins F, Synthetic
(adverse effects)
- Randomized Controlled Trials as Topic
- Sulfonamides
(adverse effects, therapeutic use)
- Thiophenes
(adverse effects, therapeutic use)
- Timolol
(adverse effects, therapeutic use)
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