The present study describes a rare case of a mesenteric
liposarcoma that resulted in a complete remission (CR) following treatment with
trabectedin (Yondelis®). The patient presented with
abdominal pain and
fever. An abdominal mass was identified that corresponded to a mixed-type high-grade mesenteric
liposarcoma with wide areas of
necrosis, areas of dedifferentiation and features of a
leiomyosarcoma. Three months after the removal of the first mass, the patient underwent a second
laparotomy, followed by treatment with
doxorubicin and
ifosfamide. Subsequently, the patient was started on
therapy with
trabectedin and a CR was noted following only four cycles of
therapy. The best responses that are reported in the literature for cases of
liposarcoma treated with
trabectedin are mostly for
liposarcomas of the myxoid/round cell type and are mainly partial responses. In the present study,
trabectedin was used for the treatment of a mesenteric
liposarcoma of mixed morphological features and a CR was achieved.